ACE Inhibitors: The Heart's Unsung Heroes | Vibepedia

Angiotensin-Converting Enzyme (ACE) inhibitors are a cornerstone of cardiovascular pharmacotherapy, primarily prescribed to manage hypertension and heart failure. Developed from snake venom peptides in the 1970s, their mechanism involves blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to vasodilation, reduced aldosterone secretion, and consequently, lower blood pressure. Beyond their antihypertensive effects, ACE inhibitors are crucial in preventing cardiac remodeling and improving survival rates in patients post-myocardial infarction and those with diabetic nephropathy. While generally well-tolerated, common side effects include a dry cough and hyperkalemia, necessitating careful patient monitoring.